Assessing the Risk of Acute Kidney Injury: A Paradigm Shift in Renal Care
Dr. V. Seenu Reddy, MD MBA, FACS, discusses the implications of NEPHROCHECK® Test [TIMP2 · IGFBP-7] to identify at-risk patients.
How can early identification of AKI affect patient outcomes?
Dr. Jeffery Vender examines how new biomarkers could benefit patients by identifying their risk for acute kidney injury earlier. AKI is often recognized late and can result in morbidity, mortality and increased cost of care.
A Familiar Danger
Acute kidney injury is an all too common complication, afflicting between 7 percent and 18 percent of all hospitalized patients4 and up to 50 % of critically ill patients.5 The condition is associated with a 10-fold increase in hospital mortality rates and a higher rate of chronic kidney disease among post-op patients.3
The Challenges of Timely Identification
While a number of acute and patient risk factors have been identified for AKI, there is no reliable way for a clinician to establish a clear risk profile.2
Delays in recognizing acute kidney injury can potentially lead to irreversible consequences,4 but the good news is that in many cases, adverse patient outcomes are avoidable if the condition is recognized and managed in a timely fashion.6
PATIENT RISK FACTORS7
CHRONIC KIDNEY DISEASE
CHRONIC DISEASE (HEART, LUNG, LIVER)
ACUTE RISK FACTORS8-11
Everything Is at Least Two to Three Times Worse
If a patient develops an acute kidney injury complication during hospitalization, short-term and long-term factors such as length of stay, hospital cost, 30-day readmissions and hospital mortality can become at least twice as severe.
The Acute Kidney Injury Effect
In a study of 27,841 adults undergoing major surgery, hospital and 90-day mortality rates were significantly higher among patients with acute kidney injury.16
More Serious than a Heart Attack
Unlike myocardial infarction, acute kidney injury’s symptoms are not usually apparent, making risk assessment difficult.2
In a study of more than 36,000 hospitalized patients, those who developed acute kidney injury without myocardial infarction had a higher mortality rate than those who suffered myocardial infarction without developing acute kidney injury.17
Acute Kidney Injury Is Twice as Deadly